macché
/mahk-KEH/ · interjection
no way / not at all / of course not
look it up on WordReference ↗In context
«Sei stanco?» «Macché, sto benissimo!»
"Tired?" "Not at all, I feel great!"
An emphatic, almost indignant "no". It knocks down the idea you've just been handed, and with feeling.